报告题目: |
Magnetically-Enhanced Chemical, Biological and Environmental Processing Using Functionalized Magnetic Nanoparticles and High Gradient Magnetic Separations |
报告人: |
T. Alan Hatton |
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美国麻省理工学院化学工程系教授
化工实习学院院长
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报告时间: |
2009-11-06 08:00 |
报告地点: |
化学工程系工物馆 324-东 会议室 |
主办单位: |
化学工程系 |
简介: |
The separation of biopharmaceutical products from production media continues to be a challenging task. Specifically, the biggest challenges in modern biopharmaceutical downstream processing are the integration of unit operations and the development of continuous type operation. Similarly, there are many challenges inherent in chemical and environmental separations that may be amenable to advanced processes based on new principles. We have explored the use of magnetic nanoparticle adsorbents for these purposes, as they offer high adsorptive capacities with minimal mass transfer resistances, and can be captured readily using High Gradient Magnetic Separation (HGMS). In a new approach for HGMS operations to make them truly continuous, we exploit the interactions of functionalized magnetic particles with magnetic field gradients, forced convective flows and large centrifugal forces to facilitate the recovery of biopharmaceuticals from the media in which they are manufactured. In this presentation, we discuss the synthesis of suitably functionalized nanoparticles, and describe our modeling and simulations of these HGMS processes. |
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