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报告题目:
"Post-translational" modification of synthetic peptides using N-alkylaminooxy amino acids(采用N-alkylaminooxy 氨基酸合成翻译后修饰多肽)
 报告人:
Prof ,Ph.D. Michael R. Carrasco
Department  of   Chemistry,  Santa  Clara University 

报告时间
9月6日上午10:00(周三)

报告地点



 
报告时间:
2006-09-06 10:00
报告地点:
清华大学化学系何添楼107会议室
主办单位:
清华大学化学系生命有机磷化学及化学生物学教育部重点实验室
  简介:

                                                              Michael R. Carrasco
                                                               Curriculum Vitae
Education and training
University of California, Berkeley
B.A. in chemistry, 1990
Highest Honors in chemistry
Highest Distinction in General Scholarship (summa cum laude)
Columbia University, New York, NY
M.A. in organic chemistry, 1991
M.Phil. in organic chemistry, 1994
Ph.D. in organic chemistry, 1995
Thesis advisor: Prof. W. Clark Still
The Scripps Research Institute, La Jolla, CA
Postdoctoral Fellow with Dr. Stephen B. H. Kent, 1995-96
Positions and employment
2004-present Associate Professor of Chemistry, Santa Clara University, Santa Clara, CA
1999-2004 Assistant Professor of Chemistry, Santa Clara University, Santa Clara, CA
1997-1999 Research Associate, Gryphon Sciences, South San Francisco, CA
1997-1999 Lecturer in Chemistry, Santa Clara University, Santa Clara, CA
Selected academic honors
Bernard Hubbard, S.J., Creative Collaboration Award, College of Arts and Sciences, Santa
Clara University, 2005
Henry Dreyfus Teacher-Scholar Award, 2004
Camille and Henry Dreyfus Faculty Start-up Award, 1999
Ford Foundation Minority Dissertation Fellowship, 1993-94
National Science Foundation Predoctoral Fellowship, 1990-93
Malcolm Miller Award for Excellence in Teaching, Department of Chemistry, Columbia
University, 1992
Elizabeth D. North Prize, Department of Chemistry, University of California, Berkeley,
1990 (departmental award at graduation)
Phi Beta Kappa, 1990-present
Chancellor's Scholarship, University of California, Berkeley, 1986-90
Camille and Henry Dreyfus National Merit Scholarship, 1986-90
Michael R. Carrasco, Curriculum Vitae, 2 of 6
Selected publications
* indicates undergraduate coauthor
Chemoselective alkylation of N-alkylaminooxy-containing peptides. Carrasco, M. R., Silva,
O.,* Rawls, K. A.,* Sweeney, M. S.,* and Lombardo, A. A.*, Org. Lett., 8, 3529-3532
(2006).
2-(N-Fmoc)-3-(N-Boc-N-methoxy)-diaminopropanoic acid, an amino acid for the synthesis
of mimics of O-linked glycopeptides. Carrasco, M. R., Brown, R. T.,* Doan, V. H.,*
Kandel, S. M.,* and Lee, F. C.*, Biopolymers (Peptide Science), 84, 414-420 (2006).
A Versatile Set of Aminooxy Amino Acids for the Synthesis of Neoglycopeptides. Carrasco,
M. R., and Brown, R. T.* J. Org. Chem., 68, 8853-8858 (2003).
Synthesis of N-Fmoc-O-(N'-Boc-N'-methyl)-aminohomoserine, an amino acid for the facile
preparation of neoglycopeptides. Carrasco, M. R., Brown, R. T.,* Serafimova, I. M.,* and
Silva, O.,* J. Org. Chem., 68, 195-197 (2003).
Dap-SL: a new site-directed nitroxide spin labeling approach for determining structure and
motions in synthesized peptides and proteins. McNulty, J. C., Thompson, D. A., Carrasco,
M. R., and Millhauser, G. L., FEBS Lett., 529, 243-248 (2002).
Synthesis of neoglycopeptides by chemoselective reaction of carbohydrates with peptides
containing a novel N’-methyl-aminooxy amino acid. Carrasco, M. R., Nguyen, M. J.,*
Burnell, D. R.,* MacLaren, M. D.,* and Hengel, S. M.,* Tetrahedron Lett., 43, 5727-5729
(2002).
Total synthesis of cytochrome b562 by native chemical ligation using a removable auxiliary.
Low, D. W., Hill, M. G., Carrasco, M. R., Kent, S. B. H., and Botti, P., Proc. Natl. Acad.
Sci. USA, 98, 6554-6559 (2001).

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