清华大学材料科学与工程研究院《材料科学论坛》学术报告

题  目：New Biocompatible Nano-Carrier System for Targeted Cell Therapy

报告人：赤池敏宏 教授

（Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology）

时  间：2009年5月26日（星期二） 9：00

地  点：清华大学材料院学术报告厅（逸夫技术科学楼2－321）

联系人：孙晓丹老师  62772977

欢迎广大师生踊跃参加

Abstract：

We have recently reported on the development of the simplest, but highly efficient genes, proteins and drugs delivery device based on generated carbonate apatite nano-crystals having high affinity to DNA but fast dissolution kinetics for effective release of DNA during vesicular acidification.

NAME  :  Toshihiro, Akaike

AFFILIATION  AND  ADDRESS: 

Department of Biomolecular Engineering,

Graduate School of Bioscience and Biotechnology,

Tokyo Institute of Technology, 4259 Nagatsuta-cho,

Midori-ku, Yokohama 226-8501, Japan

TELPHONE : +81-45-924-5790 (Tokyo Tech)

FAX :       +81-45-924-5815 (Tokyo Tech)     E-mail :  takaike@bio.titech.ac.jp

CAREER HISTORY:

1975                                University of Tokyo  Ph.D. Synthetic Chemistry  “The Stereochemistry of the Polymerization of N-Carboxy α-Amino Acid Anhydride.”

1975-1981      Research Associate, Dept. of Surgical Science, The Heart

Institute of Japan, Tokyo Women's Medical College (Presently “University”)

1980-1990      Associate Professor, Dept. of Material Systems Engineering,　Faculty of Technology, Tokyo University of Agriculture and Technology

1989-1995      Project Leader Akaike Project “High-functional Membrane for

       Molecular Recognition”, Kanagawa Academy of Sci. &Tech.

1989,1996      Visiting Professor of University of Paris XIII (France)

2000       Visiting Professor of Harbin Medical University (China)

2000-2003      Professor  of  Shinshu University Graduate School of Medicine

1990-Present    Professor of Tokyo Institute of Technology,

Graduate School of Bioscience and Biotechnology, Dept. of

Biomolecular  Engineering

SUMMARY OF PRESENT WORK:

Tissue Engineering(Regenerative Medicine), Biomedical Polymers (Blood-compatible Polymers, Cell-Matrix Engineering for Liver and ES cells),  Hybrid Artificial Organs (Liver, Pancreas), Cell Biology (Cytokines, Adhesion Molecules, Apotosis, Extracellular Matrix), Hepatology (Liver Cells Pathology & Physiology), Drug and gene Delivery Systems (Polymers & Apatite Derivatives)

HONORS

Fellow, Biomaterials Science and Engineering The International Union of Societies for Biomaterials Science and Engineering (2004)

Jorge Heller Journal of Controlled Release/CRS Outstanding Paper Award (1997)

Scientific Achievement Award (1989) The Japanese Society for Biomaterials

MAJOR PUBLICATION:

Chowdhury E.H., Nagaoka M., Ogiwara K., Zohra F.T., Kutsuzawa K., Tada S., Kitamura C., Akaike T.; Integrin-Supported Fast Rate Intracellular Delivery of Plasmid DNA by Extracellular Matrix Protein Embedded Calcium Phosphate Complexes. Biochemistry, 44, 12273-12278, (2005)

E-cadherin-coated plates maintain pluripotent ES cells without colony formation. M. Nagaoka, U.Koshimizu, S.Yuasa, F.Hattori, H.Chen, T. Tanaka, M. Okabe, K. Fukuda, and T. Akaike.　PLoS ONE, 1, e15, (2006)

The effect of natural extracellular matrix deposited on synthetic polymers on cultured primary hepatocytes.　T.Hoshiba, C-S.Cho, A.Murakawa, Y.Okahata, T.Akaike     Biomaterials, 27, 4519-4528, (2006)

Over 600 publications, 45 patents

ACTIVITIES

The Japanese Society of Regenerative Medicine Director

The Japanese Society of Tissue Engineering Director

The Japanese Society for Biomaterials Vice President, Director