Robotic systems for synthetic chemistry are becoming more common, but they are expensive, fixed to a narrow set of reactions, and must be used within a complex laboratory environment. A portable system that could synthesize known molecules anywhere, on demand, and in a fully automated way, could revolutionize access to important molecules. Here we present a portable suitcase-sized chemical synthesis platform containing all the modules required for synthesis and purification. The system uses a chemical programming language coupled to a digital reactor generator to produce reactors and executable protocols based on text-based literature syntheses. Simultaneously, the platform generates a reaction pressure fingerprint, used to monitor processes within the reactors and remotely perform a protocol quality control. We demonstrate the system by synthesizing five small organic molecules, four oligopeptides and four oligonucleotides, in good yields and purities, with a total of 24,936 base steps executed over 329 h of platform runtime.

About the speaker：Manzano Davila Juan Sebastian earned his Bachelor of Science in Chemistry from Universidad San Francisco de Quito (Ecuador) in 2013, where he conducted research on the electronic properties of pyrogallol[4]arenes using computational methods. Following that, he successfully completed his Ph.D. at Iowa State University in 2018 under the guidance of Dr. Igor Slowing. His doctoral work primarily revolved around the development of versatile 3D printable resins, crucial in crafting bespoke and chemically active 3D printed structures. He was also involved in projects exploring the application of mesoporous materials as supports in heterogeneous catalysis and drug delivery, as well as conducting QM/MM modelling of substrate-surface interactions for a better understanding of catalytic and drug delivery mechanisms.In 2019, he joined the Cronin group, where he works with 3D printed reactionware systems for the synthesis of quantum dots. Additionally, he worked in the development of an automated portable organic synthesis platform for the synthesis of complex organic molecules, oligopeptides and oligonucleotides. In 2021, he transitioned to the Cooper Group at the University of Liverpool, where he helped setting up and optimizing automated workflows for materials synthesis. By 2022, he joined Chemify as a Senior Engineer, contributing to the endeavour of digitizing organic and materials synthesis processes.