简介: |
Nanocarriers achieving high therapeutic index must be capable of simultaneously satisfying two pairs of opposite requirements at the right places, that is, “drug Retention in blood circulation vs. Release in tumor cells (2R)” and “Stealthy in blood vs. Sticky in tumor (2S)”. Besides the 2R2S capability, the feasibility of the nanocarrier materials to be proved for use as excipients (material excipentability) and the ability to establish scaling up production processes for good manufacture processes (GMP) for the nanocarrier and its formulation with drug (process scale-up ability) are other two elements indispensable for a truly translatable nanomedicine. Herein, I will present our self-assembling prodrugs approach aimed at translatable nanomedicine for cancer drug delivery. By employing drugs themselves as components of nanocarriers, we obtained prodrugs self-assembling into nanoparticles or nanovesicles with tailored sizes, high and fixed drug loading contents, and inhibited premature burst drug release. Very importantly, the nanocarriers are also characteristic by 100% loading efficiency and easy reproducible fabrication process, making it easier to establish GMP processes. Furthermore, by using intracellular responsive linkers, we can further make the nanovesicles responsive to intracellular stimuli for fast drug release.
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