The presentation will discuss the work of the BERTHA research centre. BERTHA aims to assemble, link and analyse Big Data from diverse data sources to make substantive progress in the understanding of spatial life course environmental influences on cancer, cardio-respiratory diseases, diabetes, neurological diseases, allergy, mental health and wellbeing. Data is critical to BERTHA, integrating a multitude of (Big) data sources, from individual health records, biomarkers, mobile personal sensors, social media and official government statistics to better understand how people in Denmark are exposed to