简介: |
报告人简介：
Joel Voldman is a Professor in the Electrical Engineering and Computer Science Department at MIT. He received the B.S. degree in electrical engineering from the University of Massachusetts, Amherst, in 1995. He received the M.S and Ph.D. degree in electrical engineering from the Massachusetts Institute of Technology (MIT), Cambridge, in 1997 and 2001, developing bioMEMS for single-cell analysis. Following this, he was a postdoctoral associate in George Church’s lab at Harvard Medical School, where he studied developmental biology. In 2002 he returned to MIT as an Assistant Professor in the Electrical Engineering and Computer Science department at MIT. In 2004 he was awarded the NBX Career Development Chair, in 2006 promoted to Associate Professor, and in 2013 promoted to Professor in the department. In 2018 he became Associate Head of the Department. Among several awards, he has received an NSF CAREER award, an ACS Young Innovator Award, a Bose Fellow award, Jamieson Teaching Award, Smullin Teaching Award, Quick Faculty Research Innovation Fellowship, and awards for posters and presentations at international conferences.
Prof. Voldman’s research focuses on developing microfluidic technology for biology and medicine, with an emphasis on cell sorting and stem cell biology. He has developed a host of technologies to arrange, culture, and sort diverse cell types including immune cells, endothelial cells, and stem cells. Currentareas of research include recapitulating the induction of atherosclerosis on a microfluidic chip, and using microfluidic tools to study how immune cells decide to attack tumor cells. He is also interested in translational medical work, such as developing point-of-care drop-of-blood assays for proteins and rapid microfluidic tests for immune cell activation for the treatment of sepsis.
报告摘要：
第一部分：基于细胞本征性质的微流控细胞操控工具
Microfluidic tools for manipulating cells via intrinsic properties Microsystems have the potential to impact biology and medicine by providing new ways to manipulate, separate, and otherwise interrogate cells. Simply physically manipulating cells—using microfluidics, electric fields, acoustics, etc.—provides new ways to separate cells and organize cell-cell interactions. One example illustrating the power of microscale manipulation of cells is to sort cells based on their intrinsic electrical properties. Electrical properties have previously been correlated with important biological phenotypes (apoptosis, cancer, etc.), but a sensitive and specific method approach has been lacking. We have developed a method called iso-dielectric separation that uses electric fields to drive cells to the point in a conductivity gradient where they become electrically transparent, resulting in a continuous separation method specific to electrical properties. With this method, we are developing a point-of-care assay that can quickly assay immune cell activation, which has applications for monitoring inflammation in sepsis and other immune disorders. We have also developed an acoustic version of this separation method, where an acoustic force drives cells in an acoustic gradient to their iso-acoustic point, and have used this to measure the acoustic properties of cells with unparalleled resolution and throughput. |
