Research Interests
Development of new antibiotics and compounds to treat genetic rare diseases.
The primary research objective in our lab is in the area of carbohydrate synthesis, chemical and enzymatic, to solve key biological problems by understanding bio-catalysis at the molecular level. These basic tools are tightly associated with two major goals of our research program: development of new antibacterial drugs with commercial value, and the development of carbohydrate-based drugs to treat genetic diseases. The most recent achievements of the group include (1) development of new synthetic compounds that successfully combat pathogenic bacteria and in parallel are able to delay new resistance development; (2) development of new aminoglycoside variants with an ability to fix damaged genes during the translation process; a general tool for the treatment of genetic diseases caused by nonsense mutations.