Cellular medicine holds enormous potential to treat many challenging diseases and biomaterials play an important role in many aspects of cellular medicine including cell expansion, engineering and delivery. In this talk, I will discuss our recent efforts in developing novel biomaterials for the aforementioned three aspects of cellular medicine. First, I will describe compartmentalized hydrogel microcapsules for scalable organoid culture. Organoid technology has broad applications in disease modeling and cell therapy. However, the manufacturing of organoids at a large scale has been challenging. Using small intestinal organoids as a model, I will show how advanced microcapsule designs may facilitate the scale-up of organoid culture. Second, I will describe a biomaterial approach to engineer iPS cell-derived hepatocytes and improve their engraftment in immunocompetent mice for potential applications in personalized medicine. Previously, it has been challenging to obtain functional hepatic engraftment of these cells with most studies having been done in immunodeficient animals. I will show how a 3D cell co-aggregation strategy combined with cell encapsulation using biocompatible hydrogel capsules improved the maturation and engraftment of iPS cell-derived hepatocytes. Lastly, I will discuss some new biomaterials that are under development in our lab for therapeutic cell delivery. I will show a particular application in the treatment of type 1 diabetes.