报告题目: |
Using Gene Therapy to Create a Biological Pacemaker |
报告人: |
Lepeng Zeng |
|
PhD
Medtronic, Inc. Minneapolis, MN, USA
|
报告时间: |
2010-11-03 10:00 |
报告地点: |
医学科学楼B321 |
主办单位: |
清华-霍普金斯生物医学工程联合中心/医学院生物医学工程系 |
简介: |
Implantation of an electronic pacemaker is the standard of care for patients with severe bradycardia, but such therapy has several limitations including hardware related complications, limited battery life and lack of response to autonomic and physiologic demands on the heart. With the technology advance in the field of gene and cell therapy, investigators have sought to provide a curative solution in the form of a biological pacemaker. To create a biological pacemaker, certain ion channels known for playing a critical role in the initiation of the heart beat, such as the hyperpolarization-activated cyclic-nucleotide-gated (HCN) ion channel, are delivered via viral and/or cell approaches into a normally quiescent region of the heart, thereby creating a spontaneous rhythm. Compared to its electronic counterpart, a biological pacemaker is conceptually an attractive and potentially disruptive alternative. This presentation reviews the research progress on using clinical relevant adeno-associate virus (AAV) and HCN gene to create a long-term and consistent biological pacemaker in a canine model. |
|
