摘要：One copy of the human genome comprises a primary code made up of an arrangement of just over three billion units of the DNA bases (or '"letters") G, C, A and T. While the Human Genome Project took years, thousands of instruments and several hundred million dollars to decode the first human genome, this can now be done on a single instrument in one day for a thousand dollars. In this lecture I will discuss DNA sequencing and in particular a method for rapidly decoding the genomes that originated in Cambridge in the 1990s. There are other dimensions of chemical features that constitute additional coding mechanisms in DNA and I will also discuss chemistries for decoding additional chemical and structural features of the genome. I will consider the impact of rapid genome sequencing on the life sciences, medicine and society.

海报（20190906）.pdf

人类基因组由超过30亿的DNA碱基（A, G, C, T）以特定的排列方式编码构成。在人类基因组计划实施过程中耗时数年、使用成千上万的仪器并花费数亿美元；而这些工作如今可以在一天内用一台仪器完成，花费仅一千美元。本报告将介绍20世纪90年代起源于剑桥的一种快速DNA测序以解码基因组的方法。同时，本报告也将讨论解码基因组特殊化学和结构特征的化学策略，并进一步讨论该测序策略对生命科学、医学以及整个社会的影响。