Jie Song, Ph.D.

Assistant Professor of Orthopedics and Cell Biology

University of Massachusetts Medical School

 

Regenerative medicine aspires to reduce reliance on or overcome limitations associated with donor tissue-mediated repair. A major roadblock in translating scaffold-based regenerative medicine into clinical practice is the lack of materials combining tissue-like physical and biochemical properties with desirable surgical handling characteristics to enable their safe delivery and integration with target tissue. Nanostructured material design platform provides a unique opportunity to integrate physical, biochemical, and mechanical signals for complex regenerative medicine applications. In this talk, the design and application of an elastomeric osteoconductive nanocomposite for expedited repair of critical-sized femoral segmental defect in rats, and a nanoparticle-mediated strategy towards high-performance shape memory polymer implants will be presented.