Calibration, based on data from centrifuge and shake-table experiments continues to promote the development of  more accurate computational models. Capabilities such as coupled solid-fluid formulations, and nonlinear incremental-plasticity approaches, allow for more realistic representations of the involved static and dynamic/seismic responses. In addition, contemporary high-performance parallel computing environments  are permitting new  insights, gained from analyses of entire ground-foundation-structural systems. On this basis, the horizon is expanding for large-scale numerical simulations to further contribute towards the evolution of more accurate analysis and design strategies. The studies presented herein address this issue through recently conducted  three-dimensional (3D)  representative research efforts that  simulate the seismic response of: i) a shallow-foundation liquefaction countermeasure, ii) a pile-supported wharf, and iii)  a full bridge-ground system. A discussion of enabling tools for routine usage of such 3D simulation environments is also presented, as an important element in support of wider adoption and practical applications. In this regard, graphical user interfaces and visualization approaches can play a critical role.