报告摘要：

Brain activity is distributed over the 3D volume and evolves in time. It is of importance to image dynamic brain activity with high resolution in space and time domains. Functional neuroimaging has played a significant role in advancing our ability to image brain function and dysfunction with high spatial and temporal resolution. We will review our recent efforts in developing source mapping and imaging methods to localize and image human brain activity and applications to seizure localization. We will review the merits and challenges of multi-modal functional neuroimaging, by integrating electrophysiological and hemodynamic measurements. Our recent work indicates that, the BOLD functional MRI and electrophysiological data can be integrated in a principled way, leading to substantially enhanced spatio-temporal resolution for functional imaging of dynamic brain activation. We will also discuss the co-localization of hemodynamic and electrophysiological signals associated with movement and motor imagery; and review our development of a noninvasive brain-computer interface that has demonstrated the ability for humans to control a toy helicopter by “thoughts”.