Abstract: Biomaterial-based strategies for tissue engineering span a vast spectrum from the production of scaffolds tailored with appropriate mechanical properties and degradation kinetics to serve transiently as a bridge to tissue formation to the leverage of biomaterials for the controlled delivery of biological signals to regenerate tissue in specific sites in the body. For example, our laboratory has developed a variety of biodegradable polymers for the controlled delivery of bioactive agents and/or stem cell populations to promote regeneration of tissues such as bone and cartilage. We have also applied engineered culture of cell populations on three-dimensional scaffolds toward the development of biologically active hybrid scaffold/extracellular matrix constructs for regenerative medicine applications as well as testing of anticancer drugs. This talk will present recent examples of biomaterial-based approaches for the development of tissue engineering technologies to meet clinical needs.
Mikos教授简介: Mikos教授是世界著名的生物材料领域专家。美国Rice大学Departments of Bioengineering and Chemical and Biomolecular Engineering的教授,美国国家工程院院士,美国国家医学科学院院士。国际组织工程与再生医学学会(Tissue Engineering and Regenerative Medicine International Society (TERMIS))的Founding Fellow,TERMIS美国学会前主席,美国生物材料学会(SFB)前主席。此外,他还是美国科学促进协会委员,美国化学工程师学会委员,生物医学工程学会委员,控制释放学会成员,国际生物材料科学与工程学会成员,美国国家科学院发明家。担任国际重要期刊《Tissue Engineering Part A》 《Tissue Engineering Part B: Reviews》 《Tissue Engineering Part C: Methods》的主编,并为该杂志创始主编成员。为下述期刊《Advanced Drug Delivery Reviews》 《Cell Transplantation》 《Journal of Biomaterials Science Polymer Edition》 《Journal of Biomedical Materials Research (Part A and B)》 《Journal of Controlled Release》的编委成员。 Mikos教授专心致力于新型生物材料的合成、工艺及评价技术开发,并广泛研究其应用于组织工程支架材料、药物控制释放载体、非病毒基因载体等领域。他的工作有力的推动了整形外科、口腔科、心血管科、神经学、眼科等医疗领域生物材料的发展,在国际上具有该领域的权威地位。截至2015年4月,Mikos共发表超过530篇文章,27项专利,15部著作,被引用超过47000次,H因子高达117。2011年被路透社评选为2000-2010年间排名前100的材料科学家,2014年被评为高引用科学家,引用率排名位居前1%。曾获生物材料领域的创始人奖(Founders Award)、克莱姆森奖(Clemson Award )、罗伯特.普利兹克杰演讲者奖(Robert A. Pritzker Distinguished Lecturer Award)等重要奖项。
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