His major research focuses on new NMR capability development aimed at pushing the frontier of NMR and the applications of NMR to address critical problems in the fields of catalysis science, energy storage and biomedical science, etc.  He pioneered the Combined High Temperature and High Pressure MAS NMR technique for in situ NMR investigations of reaction mechanism/dynamics, and a range of slow and ultra slow magic angle spinning, or magic angle turning (MAT) NMR techniques with sample spinning rate ranged from 1 to about 1000 Hz for enhanced spectral resolution in solids, semi-solids and biological materials.  His current research interests and expertise include (i) Developing magic angle spinning NMR metabolomics, in particular slow-MAS metabolomics, for biomedical applications; (ii) in situ and ex situ NMR characterization of heterogeneous solid catalyst materials, surface functional groups and active cites, molecular dynamics at the interface, reaction mechanisms and pathways; (iii) in situ constant flow and high pressure MAS NMR capability development; (iv) in situ NMR capability development for energy storage systems such as Li-ion and beyond Li-ion batteries; (v) ultra-high field NMR spectroscopy, quantum chemistry calculations to predict molecular geometry and the principal values of chemical shift tensors, and quadrupolar coupling constants; (vi) NMR lineshape simulation, NMR pulse sequence design, programming, and testing.