韩琳，山东大学教授，博导

 

韩琳，山东大学教授，博导，1979年2月出生于河南驻马店。1999-2003本科就读于山东大学物理与微电子学院，2003-2006 在清华大学微电子所攻读硕士学位，毕业后赴美国普林斯顿大学电子工程系攻读博士学位，研究用于柔性显示的材料与器件，并于 2011 年4 月获得博士学位。博士毕业后耶鲁大学生物医学工程系继续博士后研究，结合自身的电子工程技术，研发用于单细胞生物信息提取的微流控芯片系统,并取得了多项创新成果，获得了Connecticut Stem Cell Fund、美国国立卫生研究院（NIH）、David and Lucile Packard Foundation 等多项重大科研资助,并于2015年4月晋升为副研究员。2016年6月入职山东大学微电子学院。迄今为止，在国际学术期刊杂志上共发表学术论文 20 余篇。总引用140 余次。在美国学习和工作期间申请9 项专利，其中三项已经授权。

 

Abstract: Microfluidics is a field having a rapid growth, indeed since its dawn microfluidics applications became more and more relevant in life sciences. The reason for this success is due to the unique chemical and physical features that occur in fluids at the micron size, which allow to have several advantages over conventional “macro”-techniques. Furthermore, microfluidics devices are in general easy to use and to manufacture and yet, cost effective.Substantial evidence shows that the heterogeneity of individual cells within a genetically identical population can be critical to their chance of survival. Methods that use average responses from a population often mask the difference from individual cells. To fully understand cell-to-cell variability, a complete analysis of an individual cell, from its live state to cell lysates, is essential. Highly sensitive detection of multiple components and high throughput analysis of a large number of individual cells remain the key challenges to realise this aim. Microfluidicstechnology haS emerged as the most promising avenue to address these challenges. Here this talk will focus on the high throughput microfluidic chips to capture an individual live cell and to realize the analysis of its gene and proteins. The speaker also will discuss the opportunities that microfluidic based single cell analysis can bring into the drug discovery process.