报告摘要

Advances in optical imaging technologies have been constantly expanding our knowledge of biological systems. These achievements are made possible by synergistic collaborations between physicists/engineers who build instruments and chemists/biochemists who design probe molecules. In this talk I will introduce my selected works on using elaborately tailored synthetic molecules to advance optical imaging methods from different aspects. I will discuss the development of 1) the covalent TMP-tag for protein labeling that enables live cell multi-color fluorescence imaging, 2) an isotopic editing strategy to render alkynes as multiplexed metabolic labels for Raman imaging, and 3) a palette of isotopically edited chromophores offering 10+ resolvable vibrational colors with high sensitivity for the emerging electronic pre-resonance stimulated Raman scattering microscopy. An overarching theme of these studies is the intersection between enabling synthetic chemistry and bioconjugation, spectroscopy and biological sciences, highlighting the vital role of modern molecular probes in the development of bioimaging technologies.

 

报告人简介