The genome contains the information required to specify all cell types and functions in the body. To make sure the right cell types and functions are expressed at the right time, specific parts of the DNA that makes up the genome are used in different situations. Inside the cell nucleus, the genome exhibits a striking 3D organisation, which is dynamically adjusted to this selectiveexpression. In this talk, I will first introduce different physicalmodels that explain how this 3D organisation is established anddynamically adjusted. I will then more specifically discuss ourwork, which uses a micro-emulsion analogy to explain 3D organisationin specific sub compartments of the genome. I will touch upon ourmethods, which include zebrafish embryo cells as an experimentalmodel, live and super-resolution microscopy of DNA and itsinteraction partners, and simulation models that combine reactionnetworks and polymer arrangements. I will close with an outlook howwe envision to integrate gene regulation into our physical models,and use this as an inspiration for future DNA-based computing hardware.

报告人简介：Lennart was raised in East-Westphalia and studied physics in Bremen, Germany. He then went to Montréal, QC, Canada where he combined theory and experiment during his PhD in Physiology (2010-2014, McGill University). He then worked as a postdoc at the Center for Systems Biology Dresden, the Max Planck Institute for Molecular Cell Biology and Genetics, and the Max Planck Institute for the Physics of Complex Systems in Dresden, Germany (2014-  2018). In 2018, Lennart accepted a call as Junior Professor of Systems Biology/Bioinformatics at Karlsruhe Institute of Technology (KIT), Germany. He opened a research group that integrates wet lab work, advanced microscopy, and theoretical biophysics under the theme “Computational Architectures in the Cell Nucleus”.