A basic challenge facing the construction of fundamental theories of physics is that we have only have experimental access to coarse, low-energy probes. However, low-energy particles interact with high-energy degrees of freedom, and thus must be quantum mechanically entangled with them. In this talk I will suggest that we can use this entanglement between energy scales as a novel probe of high energy physics. In some scenarios in string theory, the consequence of this entanglement will be that low-energy observers will measure coupling constants of nature that appear to statistically variable.