Abstract

    Bioreactors play a central role in all manufacturing and remediation systems based on biotechnology. There is a wide range of biochemical engineering strategies for enhancing the efficiency of bioreactors. Here we address generic issues related to the physical, genetic and physiological constraints in bioreactor design, operation, scale-up and optimization. In particular, we will re-visit important issues related to intensification opportunities driven by substrate pretreatment, fed-batch protocols, cell-immobilization and equipment retrofits. An overview of our own research case studies with microbial fermentations and mammalian cell cultures in stirred-tank and air-lift bioreactor systems will illustrate the effectiveness of proposed innovative procedures for various bioprocesses. The relative significance of the expression system, the bioreactor and the downstream recovery of products will be noted. This is a timely appraisal of ongoing bioprocessing options in view of the current techno-economic interest in environmental pollution, energy alternatives, generic drugs and the development of new ones.

报告人简介

Biological Sketch

    Professor Murray Moo-Young is at the University of Waterloo where he is director of the Canadian Cell-Factory Bioprocessing Research Network. Jamaican-born of Chinese heritage, he received his degrees from the universities of London (BSc, PhD) and Toronto (MSc). To date, his work has produced 13 books, 9 patents and over 330 papers. He is editor of the journal Biotechnology Advances. His honors include the top awards of the Canadian Society for Chemical Engineering and the American Chemical Society, Biochemical Technology Division. He is a fellow of the Royal Society of Canada, “the highest accolade for an academic in Canada”.