报告题目: |
Electrophysiological and Anatomical Assessment of Spinal Cord Injury |
报告人: |
Angelo All |
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M.B.A., M.D.
Research Associate Faculty
Departments of Neurology and Biomedical Engineering
School of Medicine, Johns Hopkins University, USA
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报告时间: |
2009-03-05 15:30 |
报告地点: |
医学院 B321 |
主办单位: |
清华-霍普金斯生物医学工程联合中心/医学院生物医学工程系 |
简介: |
According to the NIH, among neurological disorders, spinal cord injury
(SCI)’s cost to society ranks second only after mental retardation. Even a
small number of spared fibers after SCI, with immediate treatment, can
greatly improve the quality of life of patients. Knowledge about the spared
fibers sooner rather than later will help physicians to plan strategic
treatment and limit secondary injury and devise ways to prevent progression
of the injury. In addition, research in the area of stem cell and gene
therapies aims to produce therapeutically-induced functional recovery in the
animal model, yet the existing methods lack the ability to quantitatively
measure, in vivo, the resulting regeneration and neurophysiologic recovery
of the spinal cord. This need motivates us to develop experimental methods
and quantitative assessment techniques for event-related neurological
monitoring of SCI recovery and rehabilitation. I will present experimental
methods to create calibrated SCI in two model systems: Contusion and
Experimental Autoimmune Encephalomyelitis (EAE). Next, I will present
neuro-electrophysiological function monitoring using Somatosensory Evoked
Potentials (SEP). The results from SEP signal analysis are compared with the
traditional behavioral analysis (BBB open-field test) and histology.The
second part of our research involves investigating the effects of
therapeutic hypothermia and stem cell therapy. I will present preliminary
results of the effects of temperature manipulation on the SEP signals and
the results of transplanting human embryonic stem cell derived immature
oligodendrocytes to aid recovery of spinal cord structure and function.
These two research domains form the primary focus of our long term research
on developing diagnostic and therapeutic methods for evaluating and treating
spinal cord injury.
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