Abstract
The human nervous system contains two major divisions. The central nervous system includes the brain, the spinal cord and the eye. The peripheral nervous system includes the motor, sensory and autonomic nerves that connect with all other parts of the body. The injured central nervous system cannot repair itself, and the functions of the damaged parts of the central nervous system do not recover their function. In contrast, the peripheral nervous system has a greater capacity for repair and restoration of function. We are beginning to understand some of the biological process that allow regenerative repair in the peripheral nervous system and that prevent regenerative repair in the central nervous system. For example, injured nerve cells in the peripheral nervous system change their patterns of protein synthesis after injury to support growth, but injured nerve cells in the central nervous system do not. Also, the injured peripheral nervous system provides a supportive environment for nerve cell growth, but the injured central nervous system contains growth inhibitory factors. Tissue repair scaffolds offer an opportunity to provide(1) a structural substrate for regenerative growth, (2) delivery of 'growth factors' that can stimulate the synthesis of proteins necessary for growth, and (3) incorporation of precisely placed support cells that can create an environment favorable for growth and repair of all parts of the nervous system.
CURRICULUM VITAE
DAVID J. SCHREYER, Ph.D.
Department of Anatomy and Cell Biology
College of Medicine, University of Saskatchewan
Cameco MS Neuroscience Research Center
701 Queen Street, Room 5800, Saskatoon, Saskatchewan, S7K 0M7
phone: (306) 655-8711 fax: (306) 655-8709
e-mail: david.schreyer@usask.ca
Date of Birth: April 18, 1956
Place of Birth: Amityville, New York
Citizenship: U.S.A. and Canada
Undergraduate Education: Johns Hopkins University Baltimore, MD
1973-1977
B.A., Natural Sciences, 1977
Graduate Education: Washington University St. Louis, MO
1979-1986
Ph.D., Neural Science, 1986
Post-doctoral Training: Stanford University Palo Alto, CA
1986-1990
Professional Experience: Professor
Department of Anatomy and Cell Biology
University of Saskatchewan, Saskatoon, Canada
2003-present
Visiting Professor
Department of Neurobiology and Behavior
State University of New York, Stony Brook, NY, USA
2006-2007
Director
Cameco MS Neuroscience Research Center
University of Saskatchewan, Saskatoon, Canada
1996-2006
Associate Professor
Department of Anatomy and Cell Biology
University of Saskatchewan, Saskatoon, Canada
1994-2003
Assistant Professor
Department of Physiology
Queen's University, Kingston, Canada
1991-1994
Postdoctoral Fellow
Department of Neurobiology
Stanford University, Palo Alto, CA, U.S.A.
1986-1990
Junior Specialist
Department of Anatomy
University of California, Irvine, CA, U.S.A.
1984-1985
Laboratory Research Assistant
Department of Cell Biology and Anatomy
Johns Hopkins University, Baltimore, MD, U.S.A.
1978-1979
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