Quantification of Atherosclerosis using Carotid Vessel Wall Imaging
报告人:
Bernard Chiu
PhD Senior Fellow, Department of Radiology, University of Washington, USA
报告时间:
2010-10-26 10:00
报告地点:
医学院C201
主办单位:
医学院生物医学工程系/生物医学影像研究中心
简介:
The build-up of atherosclerotic plaque within the arterial wall of the carotid arteries has been shown to be an important contributor to stroke. Quantitative measurements of the progression/regression of carotid plaque are essential to monitor patients and evaluate new treatment options for carotid atherosclerosis. Many researchers have investigated the use of 3D ultrasound (US) and magnetic resonance imaging (MRI) to quantify plaque and vessel wall volumes. However, few studies have analyzed plaque thickness as a localized property. Specific information on the location where plaque changes may facilitate a deeper understanding of natural disease progression. This talk describes the development of a method for analyzing changes in vessel-wall-plus-plaque thickness (VWT) – a localized metric quantifying the distance between the carotid wall and lumen surfaces. The resulting 3D VWT-Change maps provide rich information on the spatial distribution of plaque changes. This talk also introduces a 2D representation of 3D maps. The 2D representation allows the analysis of 3D maps in a single view, eliminating the need to study 3D maps from multiple angles, and allowing easy comparison of the locations of plaque progression/regression on 2D maps obtained for the same patient at different time points. This talk also describes how these carotid maps were utilized in three studies: (1) A study on monitoring the effect of statin therapy; (2) A study investigating the difference in VWT measurements obtained in US and MRI; and (3) A study investigating the correlation between vessel wall shear stress and the presence of intraplaque hemorrhage.
