Optical Modeling and Monitoring in Antibiotics Photodynamic Therapy
报告人:
Yongji Fu
Ph.D. Senior research scientist Sharp Labs of America
报告时间:
2010-06-24 15:00
报告地点:
医学院 B-321
主办单位:
清华-霍普金斯生物医学工程联合中心/医学院生物医学工程系
简介:
Photodynamic therapy (PDT) is an antibiotic treatment that employs oxidation by a light-activated photosensitizer (PS) to kill targeted cells such as oral bacteria. PDT is a good alternative to regular antibiotics approaches because (1) the dual selectivity of PDT (PS can target to the bacteria cells and the illumination can be directed to the infected area), and (2) the difficulty for bacteria to develop resistance to PDT. It is crucial to monitor the dosimetry of PDT to ensure antibiotics effects and avoid over dosage damage to surrounding tissues. The dosimetry monitoring includes PS dosage and light dosage. A novel analytical diffusion model is introduced to assess PS distribution during photodynamic therapy using image from confocal laser scanning microscopy. Monte Carlo simulation with heterogeneous geometry is applied to analyze the light propagation into the tooth.
