报告题目: |
Advances in Imaging In Parkinson's Disease |
报告人: |
Martin J. McKeown |
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Ph.D.
Professor of Medicine (Neurology)
Clinical Director, Pacific Parkinson’s Research Center
University of British Columbia, Canada
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报告时间: |
2011-12-19 15:30 |
报告地点: |
医学科学楼B321 |
主办单位: |
医学院 |
简介: |
The symptoms of Parkinson's disease do not become evident until the majority of dopaminergic neurons are lost. Intervention will likely be most effective before significant damage has occurred -i.e., before clinical symptoms become evident - so accurate biomarkers are desirable. Yet traditionally, imaging has been unhelpful in Parkinson's disease, being used mostly to rule out other conditions that may mimic Parkinson's. We will review advances in function neuroimaging (positron emission tomography (PET) and functional magnetic resonance imaging (fMRI)), as well as changes in structural MRI imaging that can be used to detect PD-related changes. Furthermore, we will examine the role of imaging in inferring compensatory mechanisms in Parkinson's disease, which can be demonstrated from the microscopic, synaptic level to the macroscopic, systems level. Augmentation of compensatory mechanisms, in addition to ameliorating the loss of dopaminergic neurons, may represent a joint strategy for overall minimization of disability. |
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