CEST, a new class of MRI contrast agents for molecular and cellular imaging
报告人:
Guanshu Liu
F.M.Kirby Center Kennedy Krieger Institute
报告时间:
2011-04-07 13:00
报告地点:
医学院生物医学影像中心会议室（原留学生餐厅）
主办单位:
医学院生物医学影像中心
简介:
Advanced medical imaging is central for addressing the major challenges in 21st medicine, thus is called “core interdisciplinary science”. The advances in imaging science rely on the development of novel imaging technologies beyond the state of the art. Recently Chemical Exchange Saturation Transfer (CEST) imaging has emerged as a novel MRI contrast strategy in molecular and cellular imaging. Compared to traditional T1 (e.g. Gd-DTPA or Mn2+) and T2 (e.g. SPIO) contrast agents, CEST is of great interest for its capability of being ‘switchable’ (multi-spectra imaging), ‘multi-color’ (simultaneous detection of multiple agents) and ‘smart’ (responsive to numerous biological events). In this talk, a simple overview of the principle and implementation of CEST MRI will be first given, together with some examples of early success. Then this talk will focus on introducing several recent developments in our laboratory, i.e. applying diamagnetic CEST agents to clinic relevant biomedical applications such as trafficking of CEST agent encapsulated liposomes for drug delivery and detecting gene expression and enzymatic activity in gene therapy.
