简介: |
报告摘要：According to the figures provided by the World Health Organization (WHO), cancer is a leading cause of death worldwide, accounting for 8.8 million deaths in 2015. Radiation therapy which uses X-rays to destroy or injure cancer cells, has become one of the most important modalities to treat the primary cancer or advanced cancer. The newly developed microbeam radiation therapy (MRT) uses highly collimated, quasi-parallel arrays of X-ray microbeams (typically 25 µm wide and separated by 200 µm) produced by synchrotron sources and provides tremendous promise for cancer patients through its ability to destroy tumor cells while allowing the surrounding tissue to rapidly recover. MRT represents a new paradigm in radiotherapy and has shown great promise in pre-clinical studies on different animal models. Measurements of the absorbed dose distribution of microbeams are vitally important for clinical acceptance of MRT and for developing Quality Assurance (QA) systems for MRT, hence are a challenging and important task for radiation dosimetry. On the other hand, during the traditional LINAC based radiotherapy and breast cancer brachytherapy, skin dose measurements and treatment planning also require a high spatial resolution, tissue equivalent, on-line dosimeter that is both economical and highly reliable. Such a dosimeter currently does not exist and remains a challenge in the development of radiation dosimetry. Micro-dosimeters with high spatial resolution and high sensitivity as well as tissue equivalence are also needed in radiation protection areas.
Here we report the latest developments in the X-ray radiation dosimetry for cancer treatment applications. High resolution, water equivalent, optical and passive x-ray dosimeters have been developed and constructed by using plastic scintillators and optical fibers. The dosimeters have peak edge-on spatial resolutions ranging from 50 to 500 microns in one dimension, with a 10 micron resolution dosimeter under development. The developed fiber-optic dosimeters have been test with both LINAC and synchrotron x-ray beams. The dosimeter design has potential applications in LINAC based radiation therapy and synchrotron x-ray microbeam radiation therapy where a high resolution is vital for accurate dose measurements and quality assurance. This work demonstrates that water-equivalent and high spatial resolution radiation detection can be achieved with scintillators and optical fiber systems. Among other advantages, the developed fiber-optic probes are also passive, energy independent, radiation hard and potentially cost-effective.
报告人简介：李恩邦, 博士,毕业于天津大学.曾任天津大学精密仪器与光电子工程学院教授博士生导师（天津市特聘教授）, 美国JUS Uniphase公司(悉尼)高级工程师,澳大利亚悉尼大学物理学院CUDOS(国家重点实验室)研究员及实验室主管,现就职于澳大利亚Wollongong大学物理学院.一直从事光学与光电子领域的教学、科研和技术开发方面的工作，目前主要的研究领域包括：1）光子学与光子技术(激光与光纤传感技术,光与物质相互作用理论及应用技术)；2）医学物理(生物医学成像,光学及激光技术在辐射探测及癌症治疗中的应用).已完成或正在承担多项国家自然科学基金委、澳大利亚研究基金会（ARC）、天津市科委、麻省理工学院（美国国防部DARPA）研究项目。已在国内外学术刊物（包括Nature Photonics, Nature Communications, Applied Physics Letters, Optics Letters, Optics Express ）和国际会议上发表学术论文200余篇，所发表学术论文被SCI收录论文引用超过1600次, H-index 21。获得授权发明专利35项，曾获国家发明奖1次、教育部科技进步奖2次、天津市自然科学奖1次、天津市科技进步奖1次和中国专利奖1次。
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