报告题目: |
LCP Nanoparticles for Drug and Gene Delivery |
报告人: |
Leaf Huang |
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Ph.D.
Fred Eshelman Distinguished Professor and Chair
Division of Molecular Pharmaceutics
Eshelman School of Pharmacy
Professor, Department of Biomedical Engineering
University of North Carolina at Chapel Hill, USA
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报告时间: |
2011-11-29 10:30 |
报告地点: |
医学科学楼B321 |
主办单位: |
医学院 |
简介: |
A membrane/core type nanoparticle delivery system will be discussed in the talk. The core consists of condensed DNA (LPD) or calcium phosphate amorphous precipitate (LCP). Either cores encapsulate siRNA or small molecular drugs with high efficiency. Both can resist uptake by reticuloendothelial system due to the presence of a PEG brush on the surface membrane. LCP de-assembles in the acidic endosome and releases its cargo to the cytoplasm. Additional nuclear targeting will require the presence of a peptide. Their applications for the therapy of cancer and liver diseases will be shown. |
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