It is critical time to solve the problems of current qualitative biomedical science and healthcare system.  In the first part of lecture, I will discuss nanosatellites that have multiple functions in living systems: targeting, imaging, gene delivery and regulations.  Magnetic nanosatellites are being developed as new classes of smart MRI contrast agents, molecular diagnostic probes, magnetic cell labeling and separation tools.  New paradigm of molecular optogenetics by nanosatellites is not only for the on-demand remote optical control of gene regulations, but also to create transcriptional pulses for digital biology and translational medicine.  Molecular imaging methods of wireless nanosatellites provide us a new opportunity to explore inner life of living cells for understanding signaling pathways and cellular dynamics.  Capturing the dynamics of epigenetic landscape via nanosatellites might give us insights for the rational cell reprogramming in regenerative medicine. 

In the second part of lecture, I will discuss my vision for precision cell biology and preventive personalized medicine via cellular BASICs* (Biologic Application Specific Integrated Circuits). As an example of BASICs, I will present few examples of quantitative cell biology on chip and a Self-powered Integrated Microfluidic Blood Analysis System (SIMBAS). By integrating these cellular BASICs platforms and nanoplasmonic optical antenna array, we are developing Optofluidic Application Specific Integrated System (OASIS) for label-free bioassays.  The OASIS platform allows highly multiplexed nucleic acid and protein analysis.  In summary, I will discus the critical role of 21^st precision biology for nanomedicine, molecular diagnostics, and low-cost integrative healthcare systems.

 

 

 

Prof. Luke P. Lee is Arnold and Barbara Silverman Distinguished Professor of Bioengineering at UC Berkeley.  He is also director of Biomedical Institute for Global Healthcare Research & Technology (BIGHEART), and Co-Director of Berkeley Sensor & Actuator Center.  He received both his B.A. and Ph.D. from UC Berkeley.  His current research interests are bionanoscience, biophotonics, molecular imaging of living cells, molecular diagnostics, and preventive personalized medicine by Biologically-inspired Photonics-Optofluidics-Electronics Technology and Science (BioPOETS). Prof. Lee has authored and co-authored over 250 papers on single cell analysis, optofluidics, microfluidic quantitative cell biology, biotechnology, BioMEMS, nanoplasmonic PRET, SERS for label-free detection of biomolecular interactions, optoelectronics, and SQUIDs.  http://biopoets.berkeley.edu