9. Plasmonic Nanostructures in Sensing Molecules

  9.1 Introduction

  9.2 Surface Plasmon Polariton (SPR) and Applications

     9.2.1 Earlier work in bio-sensing

     9.2.2 Industry interest/products

     9.2.3 Multi component analyses

     9.2.4 Immunogenicity

  9.3 Localized Surface Plasmon Resonance (LSPR) and Applications

     9.3.1 Nanoshells technology

     9.3.2 NIR(Near Infra-Red) photothermal therapy

     9.3.3 Bio-sensing using Nanoshells

     9.3.4 Whole Blood Immunoassay using Nanoshells

  9.4 Surface-Enhanced Raman Spectroscopy (SERS)

     9.4.1 Principle of Raman Scattering

     9.4.2 SERS Mechanism and SERS Enhancement Factors

       * SERS-Active Substrates for Biophysical Applications

       * Anti-Stokes SERS – a Two-Photon Raman Probe for Biophysics

     9.4.3 SERS Bio-sensing Applications

  9.5 Plasmonic Biosensor Challenges